Protein Details: P2X receptor C

Protein ID

ICDB_Pro_0969

Protein Name

P2X receptor C

Gene Name

p2xC; DDB_G0275191

Organism

Dictyostelium discoideum (Social amoeba)

Length

368 amino acids

AlphaFoldDB

AF-Q553Y0-F1-model_v4.pdb

Function

P2X receptors are ligand-gated ion channels that play a role in intracellular calcium signaling. ATP does not evoke inward currents in p2xC. Not essential for osmoregulation.

Sequence

MLDWDSILAYNTIKVVRIRDRRLGILHLIFMIAIISYVVIYSAIIKKGYLSIEEPVGSIRTSLWSPNQFNGNESYCKNNAKPYPYEKLDCVYYDDALALYPIGDDVGFTASTRIEISDQKANCSLMNPSCKFKTFNYSNVYLADIESFTVLIDHTMYAPSSQIQFNGGDLSGYVLDQNGNEIQLNESVNVIGVEGKPDVLEISKLLEFAGVNLDDPSLTNSSNPIRYDGCVLFVFIEYSNTFSYDLNKIKYVYSIKLVDDTIYNIPEVVILDDVNSRLYYKRHAIRLIFIQTGVIGSFNFQSLLLTLVSGLGLLTVSTLIVDQLAIRFLPQRKSYSSLKFQTTESFKMKKKIVNDDGEDKLYHNIEAL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/nature00847; 10.1038/nature03481; 10.1074/jbc.m109.045674

RefSeq

XP_643831.1